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2020 Fiscal Year Final Research Report

High-performance biomaterial with essential metal ions to supply to in the living body

Research Project

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Project/Area Number 18K04734
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 26030:Composite materials and interfaces-related
Research InstitutionTokyo Denki University

Principal Investigator

Hirakuri Kenji  東京電機大学, 工学部, 教授 (60225505)

Co-Investigator(Kenkyū-buntansha) 馬目 佳信  東京慈恵会医科大学, 医学部, 教授 (30219539)
Project Period (FY) 2018-04-01 – 2021-03-31
KeywordsZn-DLCコーティング / Zn溶出 / 骨代謝 / 深さ方向元素分析 / 骨折治療
Outline of Final Research Achievements

This study proposes that osteogenesis ability of zinc (Zn)-containing diamond-like carbon (Zn-DLC) splint was assessed in vivo experiments using a mouse model. The results of the in vivo tests using mice demonstrated that the use of Zn-DLC splints tend to stimulate the bone to grow thick. It was also shown that Zn-DLC can elute Zn even in different biological environments and that the elution amount can be the highest in an in vivo environment. These results indicate that Zn-DLC may improve upon the therapeutic effect of conventional implants with the eluted Zn in healing fractures.

Free Research Field

複合材料および界面関係

Academic Significance and Societal Importance of the Research Achievements

本研究では、DLC特有の抗血栓性、化学的安定性、低摩擦、高硬度などの静的特性に加え、生体細胞の活性化に重要な役割を演じる金属元素である亜鉛(Zn)をドープすることで、生体活性元素を含有したDLCによる表面コーティング技術のバイオマテリアルへの展開を目的とした。この研究結果を「生体内におけるZn溶出型DLC膜の骨形成促進効果」、「Z生体材料としてのZn-DLCの深さ方向におけるZn溶出特性」、「骨折治療に有効な生体材料であるZn-DLC」とした発表を行い、研究成果の社会還元に寄与した(研究発表参照)。

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Published: 2022-01-27  

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