Bio-compatible Gold Plating for Tailored Tissue Regeneration and Neural Array Implants

2019 Fiscal Year Research-status Report

• Project/Area Number: 18K04736
• Research Institution: Kanto Gakuin University
• Principal Investigator: コルドニエ クリストファー 関東学院大学, 材料・表面工学研究所, 研究員 (70724938)
• Co-Investigator(Kenkyū-buntansha): 福田 淳二 横浜国立大学, 大学院工学研究院, 教授 (80431675)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Keywords: Gold / Thiolate / Monomer complex / Auto-catalytic / Aza heterocycles / Electrochemistry / Mechanism / Tautomerization

Outline of Annual Research Achievements

In the previous year, a number of new tiopronin-Au-mercapto cyclic aza (TPN-Au-MCA) monomer gold complexes were synthesized, characterized, analyzed and evaluated. The MCA compounds could be classified into types triazole, thiadiazole, and tetrazole derivatives. Each type of compound showed unique structural and electrochemical characteristics that influenced the auto-catalytic deposition reaction.
Based on the results of the previous year, the probable mechanism responsible for the thiolate gold monomerization reaction was elucidated. This lead to further understanding of the electrochemical reactions involved that influence the auto-catalytic deposition reaction. Compounds that tautomerize between an iminothiol and thioamide were found to induce the gold thiolate monomerization reaction. Comprehension of the mechanism opened new doors to a broad range of compounds that poses the iminothiol/thioamide structure. Among the compounds that could now be strategically designed, new compounds that significantly improved the auto-catalytic electroless plating bath were identified and applied to fabrication of non-cytotoxic substrates for cell adhesion and growth into cell sheets followed by electrochemical detachment. Similarly, deposits from the improved electroless gold bath showed no signs of cyto-toxicity and were acceptable for application for tailored cell sheet fabrication.

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

After getting the NMR repaired, The mechanisms involved were comprehended in a timely fashion and we were able to get back on schedule.

Strategy for Future Research Activity

Attain some follow up data required for preparing manuscripts regarding this research and the preparation and publication of at least two journal articles documenting the findings.

Causes of Carryover

very small amount was left over. Instead of wasting it on attaining exact amount, it can be more effectively used in the next fiscal year