2020 Fiscal Year Final Research Report
Does coffee polyphenol inhibit the level of MIF and the development of inflammatory carcinogenesis.
| Project/Area Number |
18K05500
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 38050:Food sciences-related
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
武田 宏司 北海道大学, 薬学研究院, 特任教授 (60261294)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Keywords | マクロファージ遊走阻止因子 / コーヒーポリフェノール / クロロゲン酸 / 炎症 / 大腸腫瘍 |
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| Outline of Final Research Achievements |
The role of macrophage migration inhibitory factor (MIF) in inflammatory colorectal carcinogenesis and the effects of coffee polyphenol components on the regulation of MIF expression were analyzed.We found that the expression of MIF was enhanced in colorectal tissue in colorectal cancer model. Especially, it was extremely high expression in colorectal tumor cells.MIF-deficient mice presented the reduction of colon tumors in this model compared with wild type mice.Moreover, there was a tendency to decrease oxidative stress and cyclooxygenase expression in the colon tissues of MIF-deficient mice compared with wild type mice. Chlorogenic acid also suppressed MIF secretion in murine macrophage cell-line.
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| Free Research Field |
免疫学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究成果は未だその役割が解明途上のマクロファージ遊走阻止因子の新たな機能解析が明らかになったこと、特に炎症・発癌機構での役割の機能解析が進んだことが学術的な意義である。マクロファージ遊走阻止因子は未だその活性や発現を制御するような臨床開発が進まず、その中で本研究によりコーヒー成分の一つがその候補となる可能性を示唆することができたのは社会的な意義を持つといえる。
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