2022 Fiscal Year Final Research Report
New approach to non-self component recognition: elucidation of immune response regulation mechanisms based on target size.
| Project/Area Number |
18K05669
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 39050:Insect science-related
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2023-03-31
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| Keywords | 細胞性免疫 / 貪食 / 包囲化 / アワヨトウ / トランスクリプトーム |
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| Outline of Final Research Achievements |
In response to pathogenic microorganisms and parasitic insects invading the insect hemocoel, hemocytes activate cellular immune reactions such as phagocytosis and encapsulation to deal with them. This study aimed to identify new cellular immune regulatory factors through transcriptome analysis. It also sought to elucidate the interactions between these newly identified factors and known regulatory factors in order to reveal the overall picture of the cellular immune system.
As a result, several novel gene groups that specifically control phagocytosis and encapsulation were obtained. Currently, the gene function analysis of these regulatory genes is being carried out, with the almost established RNAi method being used.
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| Free Research Field |
応用動物昆虫学
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| Academic Significance and Societal Importance of the Research Achievements |
昆虫が地球上に繁栄しうる理由の一つとして、劣悪な環境でも生き延びることを可能とする強力な免疫系の存在が挙げられる。本研究により、体腔内に侵入してきた病原微生物や寄生性昆虫に対して活性化する細胞性免疫制御因子を複数同定することに成功した。これらの知見は、害虫防除において、生物農薬の効果を向上させることに寄与するとともに、病気に強い益虫の作出にも貢献できるだろう。
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