Development of vaccine for tenacibaculosis

2020 Fiscal Year Final Research Report

• Project/Area Number: 18K05811
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 40040:Aquatic life science-related
• Research Institution: Obihiro University of Agriculture and Veterinary Medicine
• Principal Investigator: Kusumoto Akiko 帯広畜産大学, 動物・食品検査診断センター, 助教 (60535326)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Keywords: 魚病 / ワクチン / 滑走運動

Outline of Final Research Achievements

Tenacibaculum maritimum is the causative agent of tenacibaculosis, which affects a large number of marine fish species and is characterized by fin and mouse erosion, and necrotic ulcers of skin. In Japan, there is no available licensed tenacibaculosis vaccine for cultured fish. Use of medicine for this disease is limited. To develop tenacibaculosis vaccine, we focused on adhesins and phage receptors of T. maritimum, because those molecules exist on bacterial cell surface and thus can be easily recognized by fish immune system. We analyzed T. maritimum mutants showing abnormal gliding motility by next-generation sequencer, and also analyzed T. maritimum-specific phages.

Free Research Field

細菌学

Academic Significance and Societal Importance of the Research Achievements

滑走細菌症は国内外の増養殖産業で問題となっている海水魚の感染症である。様々な魚種で発生し、経済的被害が甚大である。したがって、滑走細菌症のワクチンは世界的にニーズが高いと言える。滑走細菌症のワクチンが実用化されれば、商業的価値の高いものとなる。