2019 Fiscal Year Annual Research Report
トキソプラズマ原虫に対する宿主免疫系におけるIRGB6の役割の解明
| Project/Area Number |
18K05970
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| Research Institution | Osaka University |
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Principal Investigator |
李 英愛 大阪大学, 免疫学フロンティア研究センター, 特任助教(常勤) (60610681)
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| Project Period (FY) |
2018-04-01 – 2020-03-31
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| Keywords | Irgb6 / Toxoplasma gondii / Ubiquitination / Pphospholipid |
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| Outline of Annual Research Achievements |
We characterized the role of IFN-γ-inducible immunity-related GTPase Irgb6 in the cell-autonomous response against Toxoplasma gondii (T. gondii), which involves vacuole ubiquitination and breakdown. We show that Irgb6 is capable of binding a specific phospholipid on the parasitophorous vacuole (PV)membrane. Furthermore, the absence of Irgb6 causes reduced targeting of other effector IRG proteins to the PV. This suggests that Irgb6 has a role as a pioneer in the process by which multiple IRG proteins access the PV.
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[Journal Article] Initial phospholipid-dependent Irgb6 targeting to Toxoplasma gondii vacuoles mediates host defense2020
Author(s)
Lee Y., Yamada H., Pradipta A., Ma JS., Okamoto M., Nagaoka H., Takashima E., Standley D.M., Sasai M., Takei K., and Yamamoto M.
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Journal Title
Life Sci. Alliance.
Volume: 3
Pages: 1-16
DOI
Peer Reviewed / Open Access / Int'l Joint Research
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