Determining phylogenetic positions of species with accelerated evolutionary rates by genome-wide analyses: a case study on urochordate Larvaceans

2022 Fiscal Year Final Research Report

• Project/Area Number: 18K06396
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 45030:Biodiversity and systematics-related
• Research Institution: The University of Tokyo (2020-2022); National Institute of Genetics (2019); Okinawa Institute of Science and Technology Graduate University (2018)
• Principal Investigator: Inoue Jun 東京大学, 大気海洋研究所, 准教授 (10596779)
• Co-Investigator(Kenkyū-buntansha): 西野 敦雄 弘前大学, 農学生命科学部, 教授 (50343116)
• Project Period (FY): 2018-04-01 – 2023-03-31
• Keywords: ゲノム比較 / 解析パイプライン / オタマボヤ類

Outline of Final Research Achievements

In order to determine phylogenetic positions of species with accelerated substitution rates of gene sequences, I developed ORTHOSCOPE* (star). ORTHOSCOPE* estimates phylogenetic trees for all protein-coding gene sequences. By using supercomputers, users can estimate phylogenetic positions of focal species by employing gene models available from web version (https://github.com/jun-inoue/orthoscope). Moreover, users can estimate phylogenetic positions of whole genome duplications and evaluate presence or absence of horizontal gene transfer events.

Free Research Field

分子系統解析

Academic Significance and Societal Importance of the Research Achievements

学術的意義：分子系統解析を専門としない研究者であっても，遺伝子系統樹に基づいてゲノムの進化を考察できるようになった点。
社会的意義：いまだに「解析スピードが速いため巨大なデータを解析できる」だけで正確さを追求しない解析ツールが出回る本研究分野に、50 年以上の歴史をもつ分子系統解析を取り入れた解析ツールを提供することで、軌道修正のチャンスを提供した点。