Prediction of cisplatin-induced nephrotoxicity in multicycle and exploration of risk factors

2022 Fiscal Year Final Research Report

• Project/Area Number: 18K06771
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 47060:Clinical pharmacy-related
• Research Institution: Kobe Gakuin University
• Principal Investigator: Fukushima Keizo 神戸学院大学, 薬学部, 講師 (30454474)
• Co-Investigator(Kenkyū-buntansha): 杉岡 信幸 神戸学院大学, 薬学部, 教授 (40418934)
• Project Period (FY): 2018-04-01 – 2023-03-31
• Keywords: シスプラチン / 腎毒性 / 反復投与 / 慢性腎毒性 / 母集団解析 / Pharmacometrics

Outline of Final Research Achievements

Cisplatin-induced nephrotoxicity in basic experiments was well captured by the developed semi-physiological model. In addition, a direct comparison was conducted between single dosing and split dosing, in which one dose was divided into 5 continuous administration for 5 days. The results clearly showed that the split dosing regimens attenuate nephrotoxicity compared to single dosing. In clinical research, the developed model in basic experiments successfully described nephrotoxicity in multicycle, but no clinically significant risk factors were found.

Free Research Field

薬物動態

Academic Significance and Societal Importance of the Research Achievements

シスプラチンの分割投与による腎毒性軽減効果には一部の臨床研究では否定的である。本検討では、この効果を支持する基礎的エビデンスを提供することができた。また、基礎研究で構築したシスプラチン誘発性腎毒性モデルは、臨床における腎毒性を補足するには有用であり、今後の活用が期待される。