2020 Fiscal Year Final Research Report
Analysis of organ damage and oxidative stress caused by uremic toxins derived from the intestinal flora
| Project/Area Number |
18K06774
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 47060:Clinical pharmacy-related
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| Research Institution | Sojo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
瀬尾 量 崇城大学, 薬学部, 教授 (20435142)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Keywords | 腸腎連関 / 尿毒症物質 / 慢性腎臓病 / ラクツロース |
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| Outline of Final Research Achievements |
We studied the effect of lactulose on renal function in adenine-induced CKD rats and monitored uremic toxins and gut microbiota. As a result, lactulose groups improved sCr and BUN levels, and suppressed tubulointerstitial fibrosis, suggesting preventing of CKD progression by lactulose. Lac groups also lowered level of serum IS and proportions of gut microbiota producing IS precursor.
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| Free Research Field |
医療薬学
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| Academic Significance and Societal Importance of the Research Achievements |
腸内細菌はヒトが分解できない物質を分解するが，その分解物の一部は吸収されて体内に入り血流を介して種々の臓器へ作用し，病気の発症や進展に悪影響を及ぼすことが明らかとなってきている。今回得られた結果は，腸内細菌の変化が尿毒症物質の体内への移行を減少させることで，腎臓病の悪化を抑制することが可能であることを示唆するものであり，今後の腎疾患に対する新規治療法への足掛かりとなる．
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