2021 Fiscal Year Final Research Report
Study of the mechanism of polynuclear formation and its regulatory mechanism in self-beating myocardial progenitor cells ACMs
| Project/Area Number |
18K06871
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 48020:Physiology-related
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
森 雅樹 滋賀医科大学, 神経難病研究センター, 客員准教授 (10602625)
星野 真介 滋賀医科大学, 医学部, 助教 (70747576)
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Keywords | 心筋細胞 / ACMs / 心筋前駆細胞 / 多核 / 細胞融合 / 虚血耐性 |
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| Outline of Final Research Achievements |
The adult mammalian heart contains several kinds of cardiac stem or progenitor cells. Atypically-shaped cardiomyocytes (ACMs) are derived from mouse heart that spontaneously develop into beating cells. We found that the ACMs can fuse with each other to become multinucleate large beating cells.
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| Free Research Field |
細胞生理学
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| Academic Significance and Societal Importance of the Research Achievements |
心筋細胞は低酸素や機械的刺激、酸性化に感受性が高く、損傷した組織の再生は不可能である。しかし、心臓組織中に低酸素等への耐性の高いACMsが生存していることは、何らかの生理的意義をもつ考えられ、将来の再生技術への手がかりとなる可能性がある。
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