Functional analysis of anorexic N-acylethanolamine

2020 Fiscal Year Final Research Report

• Project/Area Number: 18K06915
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 48040:Medical biochemistry-related
• Research Institution: Kagawa University
• Principal Investigator: Uyama Toru 香川大学, 医学部, 助教 (30457337)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Keywords: cPLA2ε / PLA2G4E / N-アシル-PE / N-アシルエタノールアミン

Outline of Final Research Achievements

N-Acylphosphatidylethanolamine (N-acyl-PE) is a phospholipid present in biomembrane and functions as a precursor of bioactive N-acylethanolamines. Recently, the ε isoform of cytosolic phospholipase A2 (cPLA2ε, also known as PLA2G4E) was identified as Ca2+-dependent N-acyltransferase. In this study, we analyzed biological roles of cPLA2ε.

Free Research Field

脂質生化学

Academic Significance and Societal Importance of the Research Achievements

N-アシルエタノールアミンは食欲抑制や抗炎症作用などの多様な生物活性を示す。N-アシルエタノールアミンがどのように合成されるかを理解することで、食欲や炎症などを調節することが可能になるかもしれない。