validity of precancerous lesion and research for pancreatic carcinogenesis

2020 Fiscal Year Final Research Report

• Project/Area Number: 18K06982
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 49020:Human pathology-related
• Research Institution: The University of Tokyo
• Principal Investigator: Tanaka Mariko 東京大学, 医学部附属病院, 病院講師 (50645710)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Keywords: 膵臓癌 / 前癌病変 / ADM

Outline of Final Research Achievements

Starting point of pancreatic carcinogenesis is acinar-to-ductal metaplasia(ADM). Previous research of ADM was mainly based on mouse model. I revealed that human ADM was occurred in inflammatory status and expressed several organ-specific transcriptional factors within one AMD lesion.
EVI1 was an important transcriptional factor for pancreatic carcinogenesis. EVI1-depletion caused the change of microRNA expression in pancreatic cancer/duct cells.

Free Research Field

病理学

Academic Significance and Societal Importance of the Research Achievements

膵発がん初期の変化の記載はアプローチが難しくマウスモデルでの検討が主であるが、ヒト検体での現象を記述することで今後の膵癌研究の発展に貢献する意義を持つ。また、ゲノム研究の発展に伴いがんにおける遺伝子変異の描出が進んでいるが、遺伝子変異によらない発がん経路を見出すことは新たな診断・治療をもたらす可能性があると考えらえる。