Differential control of the interefon and apoptotic responses against viral infection

2021 Fiscal Year Final Research Report

• Project/Area Number: 18K07168
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 49070:Immunology-related
• Research Institution: Hokkaido University (2020-2021); The University of Tokyo (2018-2019)
• Principal Investigator: Okazaki Tomohiko 北海道大学, 遺伝子病制御研究所, 准教授 (50724598)
• Project Period (FY): 2018-04-01 – 2022-03-31
• Keywords: インターフェロン / ウイルス感染症

Outline of Final Research Achievements

We previously found a mechanism by which the host cells differentially utilized two different responses, type I interferon (IFN) production to limit viral replication and cell death to eliminate infected cells. However, it was not clear whether viral elimination could actually be achieved by the usage of two differential antiviral responses. In this study, we found that viral elimination is indeed achieved by the differential usage.

Free Research Field

免疫学

Academic Significance and Societal Importance of the Research Achievements

細胞内の翻訳後修飾を介した新たなシグナル伝達機構が存在する可能性を見出した。今後様々な生命現象において、この翻訳後修飾が機能を果たすことが明らかになると期待できる。また、ウイルス排除を担う新たな分子機構を見出すことが出来た。これらの分子機構をターゲットとした新たなウイルス感染症治療法や予防法の基盤を提供することで、成果を社会に還元できる。