2020 Fiscal Year Final Research Report
Mechanism of IL-4-mediated immune regulation by group 2 innate lymphoid cells
| Project/Area Number |
18K07187
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Review Section |
Basic Section 49070:Immunology-related
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2018-04-01 – 2021-03-31
|
| Keywords | 自然リンパ球 / IgE / IL-4 |
|---|
| Outline of Final Research Achievements |
Group 2 innate lymphoid cells (ILC2) contribute to various immunological diseases including allergic disorders. Therefore, it is urgent to elucidate the activation mechanism of ILC2. In this study, we identified a novel pathway for ILC2 activation via the calcium (Ca2+) signaling pathway. In addition, IL-4 produced by ILC2 via Ca2+ signaling promoted increased allergic susceptibility by inducing antigen-nonspecific IgE production. Taken together, we clarified the mechanism of IL-4 production by ILC2 and the novel role of IL-4-mediated by ILC2 in the pathogenesis of allergy.
|
| Free Research Field |
免疫学
|
| Academic Significance and Societal Importance of the Research Achievements |
本邦では、気管支喘息やアトピー性皮膚炎などのアレルギー性疾患は増加の一途をたどり、2人に1人が患うほど深刻化している。近年見出されたILC2は、多量の2型サイトカインを産生することで、アレルギー炎症を引き起こすことが明らかとなった。本研究では、アレルギー病態におけるILC2の新たな役割を見出したことから、アレルギー病態の理解に大きく貢献するとともに、新たな治療戦略を提案する成果を生み出した。
|
