Glycosylation and immunoglobulin signaling in malignant lymphoma

2022 Fiscal Year Final Research Report

• Project/Area Number: 18K07240
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 50010:Tumor biology-related
• Research Institution: Fukushima Medical University
• Principal Investigator: Suzuki Osamu 福島県立医科大学, 医学部, 准教授 (00325953)
• Project Period (FY): 2018-04-01 – 2023-03-31
• Keywords: 糖鎖 / 悪性リンパ腫

Outline of Final Research Achievements

In adhesion assay using B cell lymphoma cell line, cell adhesion to galectins was enhanced by anti-IgM antibody in HBL-2 cells suggesting glycosylation of IgM may be associated with cell adhesion to galectins.
In adhesion assay using Burkitt lymphoma cell line, cell adhesion to galectins was enhanced by alteration of cell surface sialylation with sialic acid analogue.
These results suggested that cell surface sialic acids may be a target for therapy of human malignant lymphoma.

Free Research Field

病理学

Academic Significance and Societal Importance of the Research Achievements

ヒト悪性リンパ腫における糖鎖の研究はきわめてすくなく、不明な点が多い。
今回の成果は、世界的にも新しい知見であると考えられる。今後とも、悪性リンパ腫における糖鎖の研究を継続していくことは、大変貴重であると考えられた。