2020 Fiscal Year Final Research Report

Development of cell therapy using human-derived injury/ischemia-induced stem/progenitor cells

Research Project

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Project/Area Number	18K07380
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 51030:Pathophysiologic neuroscience-related
Research Institution	Hyogo Medical University
Principal Investigator	Nakagomi Takayuki 兵庫医科大学, 医学部, 教授 (80434950)
Co-Investigator(Kenkyū-buntansha)	高木俊範兵庫医科大学, 医学部, 講師 (00452152) 松山知弘兵庫医科大学, 医学部, 特別招聘教授 (10219529) 吉村紳一兵庫医科大学, 医学部, 教授 (40240353) 久保秀司兵庫医科大学, 医学部, 准教授 (10441320)
Project Period (FY)	2018-04-01 – 2021-03-31
Keywords	脳梗塞 / 幹細胞 / 神経再生
Outline of Final Research Achievements	Using human-derived injury/ischemia-induced stem/progenitor cells (h-iSC), which were isolated from ischemic brain tissues of stroke patients requiring decompressive craniectomy and partial lobectomy for diffuse cerebral infarction, we transplanted h-iSC into post-stroke mouse brains to investigate the efficiency by these cells. We found that some h-iSCs survived around the injected sites and that they expressed a neuronal marker Tuj1 and MAP2. In addition, mice received h-iSC improved neurological functions compared with controls. These results indicate that h-iSC can become a novel cell-based therapy for patients with stroke in the future.
Free Research Field	再生医療
Academic Significance and Societal Importance of the Research Achievements	本研究の結果、h-iSCによる細胞移植療法は、これまで有効な治療法が限られていた脳梗塞患者に対する新規治療法になり得ることが示唆された。また、本治療法の確立及び発展は、将来、脳梗塞患者をはじめとし、様々な神経疾患に対して多大なる貢献をもたらし得ることから、本研究成果は意義あるものであると考えられた。