Reactivation of insulin receptor by using lectins derived from Cordyceps.

2020 Fiscal Year Final Research Report

• Project/Area Number: 18K07458
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52010:General internal medicine-related
• Research Institution: Nagasaki International University
• Principal Investigator: Ogawa Yukiko 長崎国際大学, 薬学部, 教授 (40275607)
• Co-Investigator(Kenkyū-buntansha): 藤井 佑樹 長崎国際大学, 薬学部, 講師 (80610063)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Keywords: 糖尿病 / インスリン抵抗性 / 冬虫夏草 / アディポネクチン / ガングリオシド

Outline of Final Research Achievements

It was clarified that the differentiation from the precursor cell to the adipocyte was observed and the lowering of the adiponectin production quantity which seems to normalize the action of insulin was suppressed by coexisting the extract from genus Cordyceps with the precursor adipocyte in which the cell differentiation is inhibited under the coexistence of TNF-α. From these results, it was found that the extract of genus Cordyceps might improve insulin resistant diabetes. In addition, it was suggested that the extract of Cordyceps sinensis might contain active components that bind to gangliosides. We will further verify the structure of recognition.

Free Research Field

糖鎖生物学、微生物学、生化学

Academic Significance and Societal Importance of the Research Achievements

食事などの取り込みにより毒性を持たない冬虫夏草の抽出液の成分が、間接的にアディポネクチンの産生を増やし、糖糖尿病の原因となる脂肪細胞の分化を促進させた結果から、インスリン抵抗性糖尿病の制御を研究する天然の分子ツールが冬虫夏草から発見された。その機序は未明であるが、糖尿病を理解し治療する新たな制御方法として、学術的、社会的に非常に有意義な知見を残すことができた。