2021 Fiscal Year Final Research Report

Exploratory research on treatments for Diabetes-related dementia

Research Project

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Project/Area Number	18K07479
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 52010:General internal medicine-related
Research Institution	Tokyo Medical University
Principal Investigator	KANETAKA HIDEKAZU 東京医科大学, 医学部, 准教授 (90385021)
Co-Investigator(Kenkyū-buntansha)	羽生春夫東京医科大学, 医学部, 特任教授 (10228520) 清水聰一郎東京医科大学, 医学部, 主任教授 (10385031) 高田祐輔東京医科大学, 医学部, 助教 (20449193) 平尾健太郎東京医科大学, 医学部, 講師 (40516639) 櫻井博文東京医科大学, 医学部, 兼任教授 (60235223) 馬原孝彦東京医科大学, 医学部, 客員教授 (70266477) 佐藤友彦東京医科大学, 医学部, 講師 (70421071)
Project Period (FY)	2018-04-01 – 2022-03-31
Keywords	レビー小体型認知症 / アルツハイマー病 / 脳血流SPECT
Outline of Final Research Achievements	The CIScore using SPECT in the AD group was significantly higher than that in the DLB groups. This suggests that the CIScore can discriminate DLB from AD, if the decrease in rCBF in the PCG is similar between them. The diagnostic accuracy of the CIScore may be low as it often shows an increase in elderly DLB patients,in whom the pathologically common form is most prevalent. Further study should include assessment of multiple components such as symptom classification and age.
Free Research Field	認知症
Academic Significance and Societal Importance of the Research Achievements	アルツハイマー病(AD)とレビー小体型認知症(DLB)の鑑別をより容易に行うことが可能となった。認知症診断の効率化は、患者側の利益だけでなく、医療従事者にも効率的で有益な情報をもたらすことが可能となった。適切な医療と介護の提供に結びつくため、本研究によって得られる成果の社会的意義は極めて大きいといえる。