• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2021 Fiscal Year Final Research Report

Investigation of treatment of Alzheimer's disease with EP2 receptor inhibitors.

Research Project

  • PDF
Project/Area Number 18K07574
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52030:Psychiatry-related
Research InstitutionKyushu University of Health and Welfare (2019-2021)
Hyogo Medical University (2018)

Principal Investigator

Nagano Takayuki  九州保健福祉大学, 薬学部, 講師 (10368516)

Project Period (FY) 2018-04-01 – 2022-03-31
Keywordsミクログリア
Outline of Final Research Achievements

Prostaglandin E2 (PGE2) increased microglial cyclooxygease (COX)-2 mRNA and protein expression. These results suggest that microglial production of PGE2, which may contribute to the increase in Alzheimer's disease brains. On the other hand, PGE2 suppresses phagocytosis and other processes of microglia. Therefore, suppression of PGE2 signaling may be a potential amelioration of Alzheimer's disease.

Free Research Field

神経精神薬理

Academic Significance and Societal Importance of the Research Achievements

今回の研究成果は、PGE2のミクログリアに対する作用について、詳細に検討されたところに学術的意義があると考えられる。これまでの過去の報告などもあわせて考えると、ミクログリアにおけるPGE2シグナルが抑制されることはアルツハイマー病の改善につながる可能性が示唆され、社会的意義もあると考えられる。

URL: 

Published: 2023-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi