2023 Fiscal Year Final Research Report
Development of a test that enables visualization and quantification of pulmonary ventilatory capacity by mapping
| Project/Area Number |
18K07649
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 52040:Radiological sciences-related
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| Research Institution | Toho University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
一林 亮 東邦大学, 医学部, 准教授 (80439934)
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| Project Period (FY) |
2018-04-01 – 2024-03-31
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| Keywords | キセノンガス / 肺機能可視化 / 肺機能定量化 |
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| Outline of Final Research Achievements |
This research is a study to develop a test that enables quantification of ventilation and visualization of ventilation by lung ventilation maps by performing multiple chest CT scans on normal volunteers inhaling xenon gas and calculating high spatial resolution map images and rate constants by fitting an exponential function to the change in Hounsfield values inside the lungs. This research is to develop a test that enables quantification of ventilation and visualization of ventilation with a lung ventilation map by calculating high spatial resolution map images and rate constants. This study was severely impacted by the Covid-19 infection and could not avoid stagnation of the study. The University Hospital also treats patients with Covid-19 infection, and it was not feasible to perform the CT scan on normal volunteers due to the possibility of infection. Considering that the subjects were normal volunteers, we could not resume the study until we were sure that the situation was safe.
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| Free Research Field |
救急医学、集中治療医学
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| Academic Significance and Societal Importance of the Research Achievements |
高齢化社会の進行、大気汚染、喫煙などの影響で、閉塞性呼吸疾患などの呼吸疾患の罹患率が上昇しており、これに対応することは喫緊の課題となっている。この病態の早期の検出は、スパイロメトリーなどの肺機能検査や、CT検査による画像検査では困難である。この肺の局所の換気能の可視化および定量化が可能となることにより、症状発現前の閉塞性呼吸疾患などの肺疾患の検出が可能になり、喫煙者に対して経時的変化を客観的に評価出来ると同時に、治療介入の時期および効果判定にも応用できる可能性がある。また、この肺機能検査法により急性期呼吸障害に対する病態解明など、より広い学術、科学技術、社会への波及効果が期待される。
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