Establishment of a new imaging technique for predicting the effect of Immune checkpoint inhibitors

2020 Fiscal Year Final Research Report

• Project/Area Number: 18K07682
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Kyushu University
• Principal Investigator: BABA SHINGO 九州大学, 大学病院, 准教授 (80380450)
• Co-Investigator(Kenkyū-buntansha): 磯田 拓郎 九州大学, 医学研究院, 助教 (90452747) ; 北村 宜之 九州大学, 大学病院, 助教 (70644722) ; 染原 涼 九州大学, 大学病院, 助教 (00778821) ; 田原 圭一郎 九州大学, 大学病院, 医員 (80769802) ; 本田 浩 九州大学, 大学病院, 教授 (90145433) ; 山田 明史 九州大学, 大学病院, 学術研究員 (00565129)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Keywords: PET検査 / 免疫チェックポイント阻害剤

Outline of Final Research Achievements

The purpose of this study is to validate the usefulness of 18F-PD-L1 PET/CT in predicting the therapeutic effect of PD-1 inhibitors and to evaluate PD-1 expression in tumors. The three specific research items planned are the establishment of an 18F-PD-L1 synthesis method, the calculation of sensitivity and specificity of 18F-PD-L1 PET based on biopsy results, and the comparison with therapeutic effects. This method will establish a non-invasive imaging method of the distribution of PD-L1 expression in tumors and its changes.In this study, we succeeded in the stable synthesis and alternate labeling of radioisotopes suitable for Pd-L1 labeling.

Free Research Field

放射線科学

Academic Significance and Societal Importance of the Research Achievements

汎用性のある18FでPD-L1抗体を標識し、臨床研究を行った報告は検索しえた限り2件しか存在せず、国内での報告はこれまでに無い。本研究により得られた結果は免疫チェックポイント阻害剤をもちいた診療に大きなインパクトを与えると思われる。