Oxysterol as a biomarker for pediatric acute liver failure

2020 Fiscal Year Final Research Report

• Project/Area Number: 18K07833
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52050:Embryonic medicine and pediatrics-related
• Research Institution: Kurume University
• Principal Investigator: Mizuochi Tatsuki 久留米大学, 医学部, 講師 (20368921)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Keywords: オキシステロール / 小児 / 肝臓病 / 急性肝不全

Outline of Final Research Achievements

In this study, we aimed to clarify whether serum and urinary oxysterol is a useful biomarker for pediatric acute live failure.
Unfortunatelly, we could not collect sufficient number of samples to clarify which oxysterol is useful. However, we identified some oxysterols may have a potential for the biomarker. Next step, we would like to collect more samples of pediatric acute liver failure to clarify which oxysterol is the best biomarker for pediatric acute liver failure.

Free Research Field

小児消化器肝臓病

Academic Significance and Societal Importance of the Research Achievements

小児急性肝不全は稀な疾患であるが、予後不良なことが多い。小児急性肝不全の症例から非侵襲的に取得できる検体を用いて、早期診断や予後予測できるバイオマーカーが見つかれば、予後改善に繋がると考えられる。本研究は小児急性肝不全の治療と予後をより良くするために有用な研究と考える。