Role of neurogenic inflammation in anaphylactic reeaction to foods

2020 Fiscal Year Final Research Report

• Project/Area Number: 18K07886
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52050:Embryonic medicine and pediatrics-related
• Research Institution: Saitama Medical University
• Principal Investigator: TOKUYAMA KENICHI 埼玉医科大学, 医学部, 教授 (30237078)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Keywords: anaphylaxis / food allergy / 花粉症食物アレルギー症候群 / CGRP

Outline of Final Research Achievements

In order to know the role of neurogenic inflammation in food-induced anaphylaxis (An), plasma calcitonin gene-related peptide levels in children with food allergy (FA) were examined before and after the appearance of An during the oral food challenge test. However, no significant changes in its levels were seen, showing no evidence for its role.
We surveyed the prevalence of systemic symptoms caused by pollen-food allergy syndrome (PFAS) in a cohort of elementary or junior high school students. As a result, approximately 30 % of children among those with PFAS showed systemic symptoms. The order of frequency in the symptoms of each organ was similar to that seen in immediate type FA, suggesting that the pathophysiological mechanism of systemic symptoms caused by PFAS and immediate type FA might be similar in some parts.

Free Research Field

小児アレルギー病学、気管支喘息、慢性咳嗽、食物アレルギー、神経原性炎症

Academic Significance and Societal Importance of the Research Achievements

PFASにより惹起される全身症状の割合や、その臓器別頻度を疫学的に解析した報告は国内のみならず国外においても少ない。本研究は、PFASの定義をフルーツ・野菜アレルギーの既往というだけでなく、花粉症が出現した後にこれらの食物に対する過敏症状が出現した症例と規定している点で、従来より正確にPFASの疫学的特徴を解析出来ていると考える。PFASによる全身症状の臓器別出現比率が、即時型食物アレルギーの報告と類似している点は異なる病型のアナフィラキシー発症の背景に共通の機序が存在する可能性を示した興味深い結果と考える。