Development of new immunoassays for biologics generated by transgenic mice method

2020 Fiscal Year Final Research Report

• Project/Area Number: 18K08002
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53010:Gastroenterology-related
• Research Institution: Shiga University of Medical Science
• Principal Investigator: Andoh Akira 滋賀医科大学, 医学部, 教授 (90252395)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Keywords: 炎症性腸疾患

Outline of Final Research Achievements

We developed new assays for serum ustekinumab trough and AUA levels. These assays might provide new insights into therapeutic drug monitoring-based management of Crohn's disease patients under ustekinumab therapy.

Free Research Field

内科学

Academic Significance and Societal Importance of the Research Achievements

完全ヒト型生物学的製剤の体内薬物動態を明らかにし、トランスジェニックマウス法による完全ヒト型生物学的製剤血中濃度と中和抗体血中濃度を指標とした完全ヒト型生物学的製剤の効果を最大限に引き出す炎症性腸疾患テーラーメイド免疫療法のストラテジーを構築する基板を確立した。