The research on regulation of vascular remodeling by CD271-positive cells

2020 Fiscal Year Final Research Report

• Project/Area Number: 18K08031
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53020:Cardiology-related
• Research Institution: Kanazawa University
• Principal Investigator: Takashima Shinichiro 金沢大学, 附属病院, 助教 (60547165)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Keywords: 末梢血白血球 / 骨髄由来細胞 / 急性冠症候群 / 血管リモデリング / バイオマーカー / NGFR

Outline of Final Research Achievements

1. Basic research: Carotid ligation-induced intimal thickening increased in the CD271-gene deficiency model. Apoptosis in the neointima formed in the CD271 gene deficiency model was reduced. Moreover, CD271-positive cells were suggested to be derived from bone marrow.
2. Clinical study: Peripheral blood CD271-positive cell count increased 1.5-fold on day 3 of an acute coronary syndrome (ACS) compared to day 0 of onset. The rate of change in plaque volume at 9 months was inversely correlated with the number of CD271-positive cells on day 0 of ACS onset. Multivariate analysis showed that the number of CD271 positive cells on day 0 of ACS onset was a negative predictor of the plaque volume change rate of the non-targeted lesion at the 9 months.

Free Research Field

血管リモデリング、再生治療

Academic Significance and Societal Importance of the Research Achievements

本研究によって、骨髄由来の末梢血白血球中のCD271が動脈硬化の病態生理に関与する可能性が示された。また急性冠症候群患者の冠動脈予後を発症時に予測する新規バイオマーカーとなる可能性が示された。将来的には新しい抗動脈硬化治療(CD271陽性細胞動員・補充治療など)の研究開発への波及効果が期待される。