2022 Fiscal Year Final Research Report

Local hyperthermia treatment for peripheral arterial disease by using gold nano-rods

Research Project

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Project/Area Number	18K08041
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 53020:Cardiology-related
Research Institution	Kyushu University
Principal Investigator	TOKUNOU Tomotake 九州大学, 大学病院, 講師 (50567378)
Co-Investigator(Kenkyū-buntansha)	樋口義洋九州大学, 大学病院, 講師 (40404032) 堀内孝彦九州大学, 大学病院, 教授 (90219212)
Project Period (FY)	2018-04-01 – 2023-03-31
Keywords	低酸素 / 血管新生 / 金ナノロッド
Outline of Final Research Achievements	Gold nano-rods, rod-shaped gold nanoparticles, act as thermal converters for photothermal therapy.　Intravenous gold nano-rods were accumulated in the reticuloendothelial system, such as liver and spleen. And the nano-rods were accumulated in the inflammatory site of heart failure model mice. In the lower limb ischemia model, unilateral femoral artery was ligated and resected, gold nano-rods were injected into the ischemic area. Local hyperthermia treatment (42 degree) was performed by using gold nano-rods and near-infrared laser. After 1 week therapy with this condition, gold nano-rods showed early improvement of ischemia, but further investigation is needed.
Free Research Field	循環器内科学
Academic Significance and Societal Importance of the Research Achievements	金ナノ粒子のフォトサーマル効果を利用して研究をおこなった。静注した金ナノ粒子は炎症部位に集積することが分かったが、下肢虚血モデルのように血流が少ない疾患では金ナノ粒子の注入方法を考える必要があった。また今回使用した棒状の金ナノ粒子（金ナノロッド）は、組織透過性の高い近赤外線領域に強い吸収域をもち、光エネルギーを熱に変換するフォトサーマル効果を利用することができた。心不全や下肢虚血には温熱療法の効果も示唆されているが、今回のように局所で温熱療法を行う手段としては選択肢の一つになりうると考える。