心不全患者の医療チームによる多面的評価と医師患者間のギャップの検証

2018 Fiscal Year Research-status Report

• Project/Area Number: 18K08056
• Research Institution: Japan Research Promotion Society for Cardiovascular Diseases
• Principal Investigator: 吉川 勉 公益財団法人日本心臓血圧研究振興会(臨床研究施設・研究部門), 内科医局, 副院長・部長 (20174906)
• Co-Investigator(Kenkyū-buntansha): 香坂 俊 慶應義塾大学, 医学部(信濃町), 講師 (30528659)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Keywords: 心不全 / レジストリ / データベース

Outline of Annual Research Achievements

＜現在までの達成度＞2019年2月6日時点で335例の症例が登録された。高齢者心不全における薬物治療の意義、突然死予測モデル、急性期陽圧換気呼吸管理の意義などについて学会報告した。すでに学会報告済の5個の課題について現在論文投稿中である。
＜今後の研究の推進方策＞心不全に伴う肺高血圧、心不全発症と大気圧との関係、クリニカルシナリオ1における急性期体重減少の意義、右心不全と低カリウム血症との関係などについて解析予定である。
＜次年度の研究費の使用計画＞引き続き症例登録に人件費が必要である。データベースの定期的なクリーニングにも経費が必要である。着実に学会発表や論文化を達成しており、出張費や印刷費に研究費を充当する予定である。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

データ登録は順調に進行している。

Strategy for Future Research Activity

引き続き登録を継続し、順次データ解析に進む予定である。

Causes of Carryover

初年度使用額が予定より下回ったため、次年度に繰り越した。

Research Products

• [Int'l Joint Research] Imperial College of London(英国)
  • Country Name: UNITED KINGDOM
  • Counterpart Institution: Imperial College of London
• [Journal Article] Association of Renin-Angiotensin System Inhibitors with Long-Term Outcomes in Patients with Systolic Heart Failure and Moderate-to-Severe Kidney Function Impairment (2019)
  • Author(s): Higuchi S, Kohsaka S, Shiraishi Y, Katsuki T, Nagatomo Y, Mizuno A, Sujino Y, Kohno T, Goda A, Yoshikawa T; West Tokyo Heart Failure (WET-HF) Registry Investigators
  • Journal Title: Eur J Int Med Volume: 999 Pages: 999
  • DOI: 10.1016/j.ejim.2019.01.014
• [Journal Article] Performance of the MAGGIC heart failure risk score and its modification with the addition of discharge natriuretic peptides in Japanese acute heart failure patients (2018)
  • Author(s): Sawano M, Shiraishi Y, Kohsaka S, Nagai T, Goda A, Mizuno A, Sujino Y, Nagatomo Y, Kohno T, Anzai T, Fukuda K, Yoshikawa T
  • Journal Title: ESC Heart Fail Volume: 999 Pages: 999-999
  • DOI: 10.1002/ehf2.12278
  • Peer Reviewed / Open Access
• [Journal Article] Validation of U.S. Mortality Prediction Models for Hospitalised Heart Failure in The United Kingdom and Japan (2018)
  • Author(s): Nagai T, Sundaram V, Shoaib A, Shiraishi Y, Kohsaka S, Rothnie KJ, Piper S, McDonagh TA, Hardman SMC, Goda A, Mizuno A, Sawano M, Rigby AS, Quint JK, Yoshikawa T, Clark AL, Anzai T, Cleland JGF
  • Journal Title: Eur J Heart Fail Volume: 20 Pages: 1179-1190
  • DOI: 10.1002/ejhf.1210.
  • Peer Reviewed
• [Journal Article] Mortality after Admission for Heart Failure in Japan Compared to The United Kingdom: Is East or West Best? (2018)
  • Author(s): Nagai T, Sundaram V, Rothnie KJ, Quint JK, Shoaib A, Shiraishi Y, Kohsaka S, Piper S, McDonagh TA, Hardman SMC, Goda A, Mizuno A, Kohno T, Rigby AS Yoshikawa T, Clark AL, Anzai T, Cleland JGF
  • Journal Title: Open Heart Volume: 999 Pages: e0000811
  • DOI: 10.1136/openhrt-2018-000811.
  • Peer Reviewed / Open Access
• [Journal Article] Outcome of Hospitalized Heart Failure in Japan and the United Kingdom Stratified by Plasma N-Terminal Pro-BNP (2018)
  • Author(s): Shiraishi Y, Nagai T, Kohsaka S, Dicken B, Goda A, Nagatomo Y, Mizuno A, Kohno T, Rigby A, Fukuda K, Yoshikawa T, Clark AL, Cleland JGF
  • Journal Title: Clin Res Cardiol Volume: 107 Pages: 1103-1110
  • DOI: 10.1007/s00392-018-1283-6.
  • Peer Reviewed
• [Journal Article] 9-year Trend in the Management of Acute Heart Failure in Japan: A Report from the National Consortium of Acute Heart Failure Registries (2018)
  • Author(s): Shiraishi Y, Kohsaka S, Sato N, Takano T, Kitai T, Yoshikawa T, Matsue: Y
  • Journal Title: J Am Heart Association Volume: 7 Pages: e008687
  • DOI: 10.1161/JAHA.118.008687.
• [Journal Article] Validation and Recalibration of Seattle Heart Failure Model in Japanese Acute Heart Failure Patients (2018)
  • Author(s): Shiraishi Y, Kohsaka S, Nagai T, Goda A, Mizuno A, Nagatomo Y, Sujino Y, Fukuoka R, Sawano M, Kohno T, Fukuda K, Anzai T, Shadman R, Dardas T, Clevy W, Yoshikawa T
  • Journal Title: J Card Fail Volume: 999 Pages: 999
  • DOI: 10.1016/j.cardfail.2018.07.463.
  • Peer Reviewed
• [Presentation] Guideline-based Medical Therapy and Its Prognostic Impact in Elderly Patients Admitted with Acute Heart Failure with Reduced Ejection Fraction (2019)
  • Author(s): 秋田 敬太郎 河野 隆志 香坂 俊 白石 泰之 長友 祐司 合田 あゆみ 水野 篤 吉川 勉
  • Organizer: 83th Annual Scientific Meeting of Japanese Circulation Society
• [Presentation] Incidence and Prediction of Sudden Cardiac Death among Heart Failure Patients: Collaborative Study of WET-HF Registry and University of Washington (2019)
  • Author(s): 福岡 良磨 河野 隆志 香坂 俊 阿部 貴行 白石 泰之 澤野 充明 長友 祐司 合田 あゆみ 水野 篤 福田 恵一 Shadman Ramin Dardas Todd Levy Wayne 吉川 勉
  • Organizer: 83th Annual Scientific Meeting of Japanese Circulation Society
• [Presentation] Optimal sampling in derivation studies determines performance of heart failure prognostic models (2019)
  • Author(s): Iwakami N, Nagai T, Furukawa TA, Tajika A, Onishi A, Nishimura K, Ogawa S, Nakai M, Takegami M, Nakano H, Kawasaki Y, Alba AC, Guyatt GH, Shiraishi Y, Kohsaka S, Kohno T, Goda A, Mizuno A, Yoshikawa T, Anzai T
  • Organizer: 83th Scientific Meeting of Japanese Circulation Society
• [Presentation] Impact of Non-invasive Positive Pressure Ventilation on Short-term Outcome for Patients with Acute Decompensated Heart Failure (2019)
  • Author(s): 雪野 碧 長友 祐司 合田 あゆみ 筋野 容守 水野 篤 河野 隆志 白石 泰之 香坂 俊 吉川 勉
  • Organizer: 83th Scientific Meeting of Japanese Circulation Society
• [Presentation] 腸腰筋面積で推定する筋肉量減少は心不全患者の退院後早期臨床イベントを予測する有用なマーカーとなる (2018)
  • Author(s): 長友祐司 船水岳大 佐地真育 吉川勉
  • Organizer: 第66回日本心臓病学会
• [Presentation] Hemoconcentration-dependent predictive value of BUN/creatinine ratio at time of discharge in patients with ADHF (2018)
  • Author(s): Sujino Y, Nakano S, Tanno J, Kanda S, Shiraishi Y, Goda A, Mizuno A, Ono M, Nagatomo Y, Kohno T, Muramatsu T, Kohsaka S, Yoshikawa T
  • Organizer: 66th Annual Scientific Session of Japanese College of Cardiology
• [Presentation] The prognostic impact of geriatric nutritional risk index at discharge in patients with acute decompensated heart failure (2018)
  • Author(s): Ono M, Mizuno A, Kohsaka S, Fukuoka R, Shiraishi Y, Kohno T, Nagatomo Y, Goda A, Sujino Y, Yoshikawa T
  • Organizer: 66th Annual Scientific Session of Japanese College of Cardiology
• [Presentation] Efficacy of RAS inhibitors depending on the renal function (2018)
  • Author(s): Komeda M, Higuchi S, Goda A, Kohsaka S, Kohno T, Shiraishi Y, Mizuno A, Nagatomo Y, Sujino Y, Yoshikawa T
  • Organizer: 66th Annual Scientific Session of Japanese College of Cardiology
• [Presentation] Predicting sudden death in Japanese heart failure patients: International validation of the Seattle Proportional Risk Model (2018)
  • Author(s): Fukuoka R, Kohno T, Kohsaka S, Shiraishi Y, Sawano M, Abe T, Nagatomo Y, Goda A, Mizuno A, Fukuda K, Shadman R, Dardes TF, Levy WC, Yoshikawa T
  • Organizer: ESC congress
  • Int'l Joint Research
• [Presentation] Psoas muscle are as a novel index of sarcopenia predicts early clinical adverse events in patients with heart failure (2018)
  • Author(s): Funamizu T, Nagatomo Y, Saji M, Yoshikawa T
  • Organizer: 22nd Scientific Meeting of Japanese HeartFailure Society
• [Presentation] 循環器専門クリニックにおける慢性心不全患者の背景因子と予後の調査 (2018)
  • Author(s): 前川順子 長町千里 吉川勉
  • Organizer: 第22回日本心不全学会