ProBNP processing in patients with acute heart failure and clinical application

2020 Fiscal Year Final Research Report

• Project/Area Number: 18K08057
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53020:Cardiology-related
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: Takahama Hiroyuki 国立研究開発法人国立循環器病研究センター, 病院, 医長 (10570301)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Keywords: 心不全 / ナトリウム利尿ペプチド / BNP / リバースリモデリング

Outline of Final Research Achievements

We completed the enrollment of the patients to this clinical study in October, 2020, and also competed the measurements of proBNP, total BNP and other biomarkers. We are proceeding the analysis and will open the data at scientific meeting. In the retrospective study, we showed the data the association of proBNP ratio with left ventricular reverse remodeling in patients with heart failure. Regarding the retrospective study, we are submitting the manuscript to the scientific journal in revision process.

Free Research Field

循環器内科学

Academic Significance and Societal Importance of the Research Achievements

心不全患者にとって左室収縮性の予測は病態予測、治療介入の決定などにおいて重要な課題であり本課題の臨床的意義は高いと考えられる。