microRNA analysis in NUT midline carcinoma

2020 Fiscal Year Final Research Report

• Project/Area Number: 18K08164
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53030:Respiratory medicine-related
• Research Institution: Asahikawa Medical College
• Principal Investigator: Okumura Shunsuke 旭川医科大学, 医学部, 助教 (10516339)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Keywords: NUT midline carcinoma

Outline of Final Research Achievements

NUT midline carcinoma is a rare but highly malignant tumor with a poor prognosis. It is often found as an incurable advanced cancer, but there is no effective and established treatment. In this study, we analyzed microRNAs as a new therapeutic target for nut midline calcium. From the results of our microRNA analysis, a microRNA called miR-21 was identified as a candidate therapeutic target. When the function of miR-21 was evaluated in an experiment using a cell line, an inhibitor of miR-21 was effective for NUT midline carcinoma.

Free Research Field

呼吸器疾患

Academic Significance and Societal Importance of the Research Achievements

現在、ナットミッドラインカルシノーマに対する有効な治療薬が無いが、我々が行った研究の結果、miR-21阻害剤がナットミッドラインカルシノーマに対して有効な治療薬である可能性が示された。今後、前臨床試験でこの阻害剤の効果をさらに評価することにより、予後不良な疾患であるナットミッドラインカルシノーマの新たな治療法として臨床応用できる期待がある。