2021 Fiscal Year Final Research Report
The role of Dicer in the progression of chronic kidney disease and search for new therapeutic targets
Project/Area Number |
18K08197
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 53040:Nephrology-related
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Research Institution | Asahikawa Medical College |
Principal Investigator |
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Project Period (FY) |
2018-04-01 – 2022-03-31
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Keywords | 慢性腎臓病 / 線維化 / microRNA |
Outline of Final Research Achievements |
The purpose of this study is to explore the pathogenic mechanism and and new therapeutic targets of "Chronic kidney disease (CKD)", which is attracting attention as a new national disease. By focusing on the role of Dicer, which is an RNase that processes precursor of microRNAs, in PDGFRβ-positive cells and elucidating the mechanism of cytotoxicity in the progression of CKD, we searched for new biomarkers and new therapeutic targets. Studies using PDGFRβ-positive cell-specific Dicer-deficient mice revealed that the miR-9-5-p/Pdgfrb system is involved as a key target in the progression of renal interstitial fibrosis.
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Free Research Field |
腎臓内科学
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Academic Significance and Societal Importance of the Research Achievements |
新たな国民病として注目されている「慢性腎臓病(Chronic kidney disease: CKD)」の新たな治療標的の候補因子が抽出されてきており、国民の健康寿命延伸、QOL維持向上に寄与し得る社会的意義の高い研究成果が得られている。
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