2020 Fiscal Year Final Research Report
Vascular health and vitamin D under uremic condition
Project/Area Number |
18K08253
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 53040:Nephrology-related
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Research Institution | Showa University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
緒方 浩顕 昭和大学, 医学部, 教授 (30296959)
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Project Period (FY) |
2018-04-01 – 2021-03-31
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Keywords | 血管石灰化 / カルシトリオール / VDR |
Outline of Final Research Achievements |
Rat aortic rings and HUVECs were incubated in the normal or the high Ca/high P media. Aortic Ca content, and mRNA levels of endothelial cell markers (CD31, VE-cadherin, and ZO-1) and permeability were studied, respectively. Also, the effect of calcitriol on vascular calcification was studied by using vascular smooth muscle cell-specific VDR conditional knockout mice. Calcitriol inhibited exacerbation of vascular calcification by the suppression of HUVEC hyperpermeability. Moreover, calcitriol-VDR axis could not be involved in the progression of vascular calcification induced by high doses of calcitriol.
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Free Research Field |
腎臓内科学
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Academic Significance and Societal Importance of the Research Achievements |
本研究により、活性型ビタミンDのカルシトリオールは、CaやPのミネラル負荷による血管内皮細胞障害の抑制作用を有し、また、VDRを介した血管石灰化促進作用はみられなかったことから、ミネラル代謝異常を引き起こさないように適切に使用することにより、血管保護作用が期待されることから、動脈硬化対策の選択肢のひとつとなり得る。
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