2021 Fiscal Year Final Research Report
Development for effective induction of memory CD8 T cell against influenza virus.
| Project/Area Number |
18K08456
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 54030:Infectious disease medicine-related
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| Research Institution | International University of Health and Welfare (2019-2021)
Institute of Physical and Chemical Research (2018) |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Keywords | インフルエンザ / CD8 T細胞 / 免疫記憶 |
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| Outline of Final Research Achievements |
During the cellular adaptive immune response, CD8 T lymphocytes play a central role in mediating protection against myriad infectious pathogens. To investigate the role of TCR-pMHC interaction in regulating lung CD8 tissue-resident T cell (TR) differentiation, polyclonal responses were compared against NP366-374/Db and PA224-233/Db, two immunodominant epitopes that arise during influenza A infection in mice. We investigate 1) the memory niche where influenza-antigen specific memory CD8 T cells are generated, 2) the micro-enviroment which gives the interaction with other type of cells and 3) the adhesion molecules on the CD8 T cell which foster the persistance within the airway epithelium.
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| Free Research Field |
免疫学
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| Academic Significance and Societal Importance of the Research Achievements |
我々はメモリーCD8 T細胞が形成される“場”のモデルを提唱した。血管と細気管支に近接した粘膜固有層（従来のiBALTとは異なる部位）において、血流を介してCD8 T細胞が集簇する。そこでは、肺マクロファージがTGF-βやIL-15を発現し、一方CD11c陽性樹状細胞がIL-15受容体αを介して、CD8 T細胞にメモリー形質を与える。そして、いくつかは、気道上皮間に移動し、接着分子を介して局在し、次の感染に備えて残留する。こういった、免疫記憶を成立させる微小環境の解明の一端は、今後のウイルスパンデミックに大いに役立つものと考えられる。
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