2021 Fiscal Year Final Research Report
Neutrophils in inflammatory response induced by lipid crystals
| Project/Area Number |
18K08485
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 54040:Metabolism and endocrinology-related
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
高橋 将文 自治医科大学, 医学部, 教授 (40296108)
木村 博昭 自治医科大学, 医学部, 講師 (70593622)
渡邊 幸子 自治医科大学, 医学部, 助教 (80770619)
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Keywords | 好中球 / インフラマソーム / マクロファージ / コレステロール結晶 |
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| Outline of Final Research Achievements |
Cholesterol crystals deposited in atherosclerotic lesion activates NLRP3 inflammasome and induce inflammatory responses via interleukin-1. In this study, we investigated the involvement of IL-1 in cholesterol crystal-mediated neutrophil infiltration and found that IL-1α plays a pivotal role in this response. Our results indicate that IL-1α is an essential mediator in the inflammatory response induced by crystals and particles.
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| Free Research Field |
代謝学
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| Academic Significance and Societal Importance of the Research Achievements |
近年，心・血管病の予防における炎症性サイトカインIL-1βの重要性は臨床研究によっても示唆されている．本研究によりIL-1βだけでなく，IL-1αも重要な炎症の惹起因子であることが示されたことは，IL-1経路の阻害剤を治療に用いる上で，重要な知見になると期待される．
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