2021 Fiscal Year Final Research Report
Near-infrared fluorescence imaging and photodynamic therapy with indocyanine green lactosome has antineoplastic effects for gallbladder cancer
Project/Area Number |
18K08661
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 55020:Digestive surgery-related
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Research Institution | Kansai Medical University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
石崎 守彦 関西医科大学, 医学部, 講師 (10509467)
松井 康輔 関西医科大学, 医学部, 講師 (40460828)
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Project Period (FY) |
2018-04-01 – 2022-03-31
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Keywords | 胆嚢癌 / ICGラクトソーム / Photodynamic Therapy |
Outline of Final Research Achievements |
ICG-lactosomes accumulated in xenograft tumors and PDT had an antitumor effect on these malignant tumors. NIF imaging with ICG-lactosomes and PDT may be useful diagnostic and/or therapeutic agents for gallbladder cancer. this study suggests that ICGlactosomes are useful as novel diagnostic and therapeutic agents for gallbladder cancer. In the future, this research group will optimize the dose and irradiation conditions of the drug and consider the treatment effects on other carcinomas to develop this treatment for clinical applications. PDT with ICG-lactosomes used in the present study can be repeated and be used for endoscopic and laparoscopic treatments for gallbladder cancer.
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Free Research Field |
肝臓外科
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Academic Significance and Societal Importance of the Research Achievements |
ICGラクトソームは腫瘍選択性と局所滞留機能を有し、術中腫瘍の範囲や腫瘍残存を確認可能である。腫瘍追加切除やPDTを行なう事が可能となり、局所根治性の向上が期待できる。
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