Development of prevention of severe heart failure by endoscopic cell transplantation

2020 Fiscal Year Final Research Report

• Project/Area Number: 18K08756
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 55030:Cardiovascular surgery-related
• Research Institution: Osaka University
• Principal Investigator: MORI Daisuke 大阪大学, 医学系研究科, 特任助教(常勤) (90735185)
• Co-Investigator(Kenkyū-buntansha): 谷岡 秀樹 大阪大学, 医学部附属病院, 医員 (10815509)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Keywords: 重傷心不全予防 / 脂肪由来間葉系幹細胞 / 内視鏡的細胞移植

Outline of Final Research Achievements

We have developed a technique for endoscopically transplanting adipose-derived mesenchymal stem cells into a porcine myocardial infarction model using the cell spray method. After cell transplantation using this method,cardiac function improved and its effectiveness could be confirmed.We have developed balloon stabilizers and quattro sprays, which are auxiliary devices for endoscopic cell spraying, and are considering applying for a patent.
In the future,we will make presentations at academic conferences on research results and continue research toward practical use.

Free Research Field

心臓血管外科学

Academic Significance and Societal Importance of the Research Achievements

この方法が確立すれば低侵襲に心臓表面に細胞を移植することができ、患者さんの負担が軽減される。また間葉系幹細胞は虚血性心筋症の増悪を予防することが期待できるため、将来的に心不全予防治療になると考えられる。