2020 Fiscal Year Final Research Report
Development of a definitive diagnosis of perioperative anaphylaxis: measurement of antigen-specific IgE and urinary markers
| Project/Area Number |
18K08809
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 55050:Anesthesiology-related
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| Research Institution | Gunma University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
村田 幸久 東京大学, 大学院農学生命科学研究科(農学部), 准教授 (40422365)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Keywords | アナフィラキシー |
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| Outline of Final Research Achievements |
In this study, urine samples were collected from patients who developed anaphylaxis during the perioperative period, and the Tetranor-PGDM concentration was measured. So far, urine samples for 11 cases have been collected, and measurement of Tetranor-PGDM concentration by mass spectrometer has been completed in all cases. As a result, changes in Tetranor-PGDM concentration in perioperative anaphylaxis cases are becoming clear. Applicants are also working on the development of a blood-specific IgE measurement method for sugammadex.
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| Free Research Field |
麻酔科学
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| Academic Significance and Societal Importance of the Research Achievements |
申請者らが研究対象としてきた周術期アナフィラキシーにおいて、技術と経験の蓄積によって、皮膚テストとBATの診断精度は高まった。しかし、患者によっては侵襲のある皮膚テストを敬遠し、検査が行えないことがある。しかし、今回の開発対象となる特異的IgE測定や尿中マーカーが実用化されれば、低侵襲で実施可能な検査の選択肢が増えることになり、研究開発の意義は大きいと考える
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