New approach for treatment of septic encephalopathy

2020 Fiscal Year Annual Research Report

• Project/Area Number: 18K08888
• Research Institution: Hiroshima University
• Principal Investigator: 細川 康二 広島大学, 病院(医), 講師 (70568188)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Keywords: 敗血症性脳症

Outline of Annual Research Achievements

全身性の感染による敗血症時に高次脳機能障害が生じる。この脳障害、敗血症性脳症（sepsis associated encephalopathy, SAE）の発生機序の解明と治療法の開発を目指している。小動物を使った脳組織学的な研究と脳機能の評価から、SAEには、脳内のミクログリアの活性化が関わっており、うつ状態で増加する神経炎症のマーカーであるTSPOというミトコンドリア膜タンパクの系が関連することが示された。データベースを用いた臨床研究では、感染などによる小児急性心筋炎の治療状況を整理した。同程度に重症な患者群をとってみると、比較的症例が多い施設での生存率が高く、スケールメリットが認められた。脳波とSAEとの関連を調べる研究は少なく今後のさらなる研究が必要である。

Research Products

• [Journal Article] Pediatric Fulminant Myocarditis in Japan (2021)
  • Author(s): Ohki Shingo、Hosokawa Koji、Tomioka Shinichi、Matsuoka Masumi、Fushimi Kiyohide、Matsuda Shinya、Shime Nobuaki
  • Journal Title: Pediatric Critical Care Medicine Volume: Publish Ahead of Print Pages: －
  • DOI: 10.1097/PCC.0000000000002692
  • Peer Reviewed
• [Journal Article] Hypothermia, Poorly Recognized by clinicians, is associated with Higher Mortality Among Critically Ill Patients with infections: A Retrospective Observational Study (2021)
  • Author(s): Yamaga Satoshi、Kawabata Ayaka、Hosokawa Koji、Shime Nobuaki
  • Journal Title: Journal of Infection and Chemotherapy Volume: 27 Pages: 540～543
  • DOI: 10.1016/j.jiac.2020.12.016
  • Peer Reviewed
• [Journal Article] Pharmacological and Genetic Inhibition of Translocator Protein 18 kDa Ameliorated Neuroinflammation in Murine Endotoxemia Model (2020)
  • Author(s): Giga Hiroshi、Ji Bin、Kikutani Kazuya、Fukuda Shuji、Kitajima Takashi、Katsumata Seishi、Matsumata Miho、Suhara Tetsuya、Yamawaki Shigeto、Shime Nobuaki、Hosokawa Koji、Aizawa Hidenori
  • Journal Title: Shock Volume: Publish Ahead of Print Pages: －
  • DOI: 10.1097/SHK.0000000000001703
  • Peer Reviewed
• [Journal Article] Factors related to memory absence and delusional memories in patients in intensive care units managed with light sedation (2020)
  • Author(s): Noguchi Ayako、Hosokawa Koji、Amaya Fumimasa、Yokota Isao
  • Journal Title: Intensive and Critical Care Nursing Volume: 59 Pages: 102830～102830
  • DOI: 10.1016/j.iccn.2020.102830
  • Peer Reviewed
• [Journal Article] Microglial translocator protein and stressor-related disorder (2020)
  • Author(s): Kikutani Kazuya、Giga Hiroshi、Hosokawa Koji、Shime Nobuaki、Aizawa Hidenori
  • Journal Title: Neurochemistry International Volume: 140 Pages: 104855～104855
  • DOI: 10.1016/j.neuint.2020.104855
  • Peer Reviewed
• [Journal Article] Neutrophil gelatinase-associated lipocalin in acute kidney injury and sepsis: a retrospective study (2020)
  • Author(s): Fujino Mitsuhiro、Hosokawa Koji、Ote Hiroyuki、Shime Nobuaki、Nishiyama Kei、Kooguchi Kunihiko、Fukui Michihiko
  • Journal Title: Journal of the Japanese Society of Intensive Care Medicine Volume: 27 Pages: 483～485
  • DOI: 10.3918/jsicm.27_483
  • Peer Reviewed
• [Journal Article] Early Tracheostomy in Brain Injury: More Details Are Needed for Seeking Best Practice (2020)
  • Author(s): Hosokawa Koji、Ishii Junki、Ota Kohei、Shime Nobuaki
  • Journal Title: Critical Care Medicine Volume: 48 Pages: e984～e985
  • DOI: 10.1097/CCM.0000000000004424
  • Peer Reviewed