New approach for treatment of septic encephalopathy

2020 Fiscal Year Final Research Report

• Project/Area Number: 18K08888
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 55060:Emergency medicine-related
• Research Institution: Hiroshima University
• Principal Investigator: HOSOKAWA KOJI 広島大学, 病院(医), 講師 (70568188)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Keywords: 敗血症性脳症

Outline of Final Research Achievements

Systemic infections and inflammation often cause brain dysfunction. Our research seeks mechanism and therapeutic intervention of sepsis associated encephalopathy, SAE. From histologically studies and evaluation of brain function using small animals, SAE proved to be involved in the activation of microglia in the brain. TSPO, that is accumulated when depression model of animals and human, increased in SAE model animal. We also conducted a clinical study, in which the treatment status of fulminant acute myocarditis in pediatric patients were summarized. Higher volume of treatment number in a single institute was statistically associated with better survival. The scale merit of survival was observed. We revealed that research evaluated on the treatment of EEG and SAE was scare. Next studies are needed.

Free Research Field

救急医学

Academic Significance and Societal Importance of the Research Achievements

敗血症に関連する脳障害は、敗血症からの回復後の高次機能低下につながりADL低下をもたらす。そのためこの脳障害の発生を減らし、その程度を軽減する方法を開発することは意義がある。全身性の炎症に伴う神経炎症マーカーが増加することが発生に関連することを示したことで、治療介入の糸口になる可能性に期待が持てる。本研究の強みは臨床研究と基礎研究を合わせて行うことであるが、小児の重症心筋炎については、データベースを用いた研究からは比較的症例の多い施設での生存率が高いことが示された。