Functional Analysis of Innate Lymphoid Cell in sepsis.

2022 Fiscal Year Final Research Report

• Project/Area Number: 18K08928
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 55060:Emergency medicine-related
• Research Institution: Aichi Medical University
• Principal Investigator: Tsuda Masanobu 愛知医科大学, 災害医療研究センター, 教授 (70506683)
• Co-Investigator(Kenkyū-buntansha): 武山 直志 愛知医科大学, 医学部, 特命教授 (00155053)
• Project Period (FY): 2018-04-01 – 2023-03-31
• Keywords: Innate Lymphoid Cell / 敗血症 / 免疫抑制 / Immunoparalysis

Outline of Final Research Achievements

In this study, we analyzed the function of Innate Lymphoid Cell (ILC), a lymphocyte of the innate immune system, in sepsis.
Comparison of septic patients admitted to the intensive care unit and non-septic patients admitted to the EICU (trauma, subarachnoid hemorrhage, burns, post-cardiopulmonary arrest syndrome, acute drug intoxication, etc.) showed that ILC-1 cells were significantly (0.32 ± 0.03% in the septic group and 0.40 ± 0.03% in the non-septic group) higher in the lymphoid cells than in the septic group. The sepsis group showed significantly higher levels (p>0.05: Mann-Whitney test) than the non-sepsis group (0.32 ± 0.03%). On the other hand, NK cells, which play an important role in the innate immune system, were 13.5 ± 2.0% in the septic group and 14.7 ± 1.4% in the non-septic group, showing no significant difference.

Free Research Field

免疫

Academic Significance and Societal Importance of the Research Achievements

今回の検討では敗血症患者においてILC細胞が減少している結果となった。このことは敗血症における免疫抑制の一因を担っていると考えられる。実際に単球中のHLA-DR陽性細胞も敗血症では（48.0 ± 6.0％）非敗血症（74.0 ± 5.0％）と比べ有意（p<0.05: Mann-Whitney test）に減少しており、敗血症における免疫抑制の理由の一つを示唆される結果となった。