Therapeutic effects of TNF-a inhibitors on memory impairment after cardiopulmonary arrest resuscitation

2023 Fiscal Year Final Research Report

• Project/Area Number: 18K08930
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 55060:Emergency medicine-related
• Research Institution: Fukuoka University
• Principal Investigator: Wakasaki Rumie 福岡大学, 医学部, 講師 (20461527)
• Co-Investigator(Kenkyū-buntansha): 山浦 健 九州大学, 医学研究院, 教授 (70264041) ; 根本 隆行 福岡大学, 医学部, 准教授 (90506833)
• Project Period (FY): 2018-04-01 – 2024-03-31
• Keywords: 虚血再灌流障害 / 脳障害 / 腎障害

Outline of Final Research Achievements

While the rate of cardiopulmonary resuscitation of patients suffering from cardiopulmonary arrest has improved, it has become a serious problem that post-resuscitation patients develop organ damage such as encephalopathy and renal failure. The pathogenesis of these diseases is still unclear, and at present no effective treatment method has been established. It has been suggested that activation of inflammatory cells caused by cardiopulmonary resuscitation may induce cell death in various organs, but the detailed mechanism is unknown. In this study, we revealed that activation of inflammatory cells after cardiopulmonary resuscitation or ischemia-reperfusion is dependent on Ca 2+ signals with relevant cells.

Free Research Field

医歯薬学

Academic Significance and Societal Importance of the Research Achievements

蘇生後脳症の患者の中には記憶障害のみが残存し社会復帰が困難な場合がある。この様な記憶障害を持つ患者数が増加することは、社会的損失となる可能性がある。また蘇生後の腎機能障害も同様であり、特に末期腎不全に至る場合には社会復帰に大きな障害となる。本研究では、心肺停止蘇生後の脳および腎機能障害に対する新規治療法の開発を目指すべく、脳・腎臓における蘇生後病態発症機構の分子基盤を明らかにすることを目的としている。