Development of methods for optimization of deep brain stimulation parameters by establishing the biomarders indicating severity in Parkinson's disease

2023 Fiscal Year Final Research Report

• Project/Area Number: 18K08956
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56010:Neurosurgery-related
• Research Institution: Fukuoka University
• Principal Investigator: Morishita Takashi 福岡大学, 医学部, 講師 (20750756)
• Project Period (FY): 2018-04-01 – 2024-03-31
• Keywords: パーキンソン病 / 生体指標 / 近赤外光

Outline of Final Research Achievements

This study aims to optimize deep brain stimulation (DBS) therapy for patients with Parkinson's disease. Primarily, it involves using a device based on near-infrared spectroscopy (NIRS) to measure brain activity, with the goal of establishing effective biomarkers and exploring stimulation conditions based on these markers. Additionally, through a multi-center collaborative study, the research identifies the optimal electrode placement sites and neural fiber tracts using new brain stimulation devices to enhance the effectiveness of DBS. This approach aims to set treatment conditions tailored to each patient, thereby improving therapeutic outcomes and the quality of life for patients.

Free Research Field

脳神経外科学

Academic Significance and Societal Importance of the Research Achievements

学術的には、脳深部刺激療法の刺激条件最適化に寄与する新しい知見を提供し、パーキンソン病の重症度評価における生体指標の確立を進めることができた。社会的には、パーキンソン病患者の治療効果を向上させ、生活の質を改善することが期待される。これにより、　脳深部刺激療法の臨床応用がさらに進展し、より多くの患者に恩恵がもたらされる可能性がある。また、治療の個別化が進み、医療費の削減や患者の負担軽減にもつながると考えられる。