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2020 Fiscal Year Final Research Report

The Development of system for drug delivery to the bones using low molecular weight heparin to promote bone regeneration

Research Project

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Project/Area Number 18K09023
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56020:Orthopedics-related
Research InstitutionGifu University

Principal Investigator

Nozawa Satoshi  岐阜大学, 医学部附属病院, 講師 (20771679)

Co-Investigator(Kenkyū-buntansha) 秋山 治彦  岐阜大学, 大学院医学系研究科, 教授 (60402830)
Project Period (FY) 2018-04-01 – 2021-03-31
Keywords低分子ヘパリン
Outline of Final Research Achievements

We successfully made special low molecular weight heparin with some conjugation. The products were purified by molecular selective column.
A day after we applied the conjugates with FITC in P5 mice, it was delivered to the bone tissue specifically.

Free Research Field

脊椎脊髄外科

Academic Significance and Societal Importance of the Research Achievements

我々の開発した化合物とBMPやFGFと併用することにより、従来骨癒合の遷延がみられた部位(脊椎固定術における椎間移植骨など)の骨癒合を促進させることが期待される。これにより、患者の外固定装着期間を短縮させられる可能性があり、社会的に有益な研究である。

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Published: 2024-01-30   Modified: 2025-01-30  

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