2020 Fiscal Year Final Research Report

Development of diagnosis of lymph node metastasis in uterine cancer by superparamagnetic iron oxide

Research Project

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Project/Area Number	18K09241
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 56040:Obstetrics and gynecology-related
Research Institution	Kindai University
Principal Investigator	SUZUKI Ayako 近畿大学, 医学部, 非常勤講師 (90378696)
Co-Investigator(Kenkyū-buntansha)	松村謙臣近畿大学, 医学部, 教授 (20452336) 村上幸祐近畿大学, 医学部, 講師 (60734671) 佐藤隆夫近畿大学, 大学病院, 教授 (70162443) 柏木伸夫大阪大学, 医学系研究科, 特任教授(常勤) (30752745)
Project Period (FY)	2018-04-01 – 2021-03-31
Keywords	超常磁性酸化鉄（SPIO） / SPIO造影MRI / リンパ節転移 / センチネルリンパ節 / 鉄染色
Outline of Final Research Achievements	In this study, we aimed to develop a novel method for the diagnosis of lymph node metastasis in cervical and endometrial cancers using Super Paramagnetic Iron Oxide (SPIO). Contrast-enhanced magnetic resonance imaging (MRI) of the cervix using superparamagnetic iron oxide (SPIO) showed a preoperative positive diagnosis rate of 85%, which was higher than that of CT (67%) and PET-CT (71%). In addition, it was suggested that SPIO could be an alternative tracer to radioisotope, and that sentinel lymph nodes could be identified using SPIO.
Free Research Field	医学
Academic Significance and Societal Importance of the Research Achievements	本研究により、治療前のリンパ節転移診断の精度が上昇し、正確なセンチネルリンパ節の検出が可能となり、従来見逃されていたLN転移が検出できるようになれば、患者の予後やQuality of life（QOL）の飛躍的な改善につながり、医療費削減や社会生産性の低下防止が期待できる。