2021 Fiscal Year Final Research Report
Host Immunity for Head and Neck Cancer Stem Cells
| Project/Area Number |
18K09355
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 56050:Otorhinolaryngology-related
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Keywords | ALDH1A1 / CD39 / Foxp3 |
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| Outline of Final Research Achievements |
Tumor infiltrating lymphocytes (TILs) were observed CD39. That was showed those TILs attacked cancer cells. And TIL were also observed Foxp3. That means those TILs were exhausted after attacking cancer cells. CD44richALDHA1rich cancer cells were thought as cancer stem cells of heaad and neck cancer. When CD44richALDHA1rich cancer cells were rich in tumor, CD39richFoxp3rich TILs were poor in the maicro enviroment cancer tissue.
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| Free Research Field |
頭頸部癌
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| Academic Significance and Societal Importance of the Research Achievements |
担がん宿主免疫より逃避する機序の解明につながる。免疫チュックポイント阻害薬を投与しても担がん宿主免疫能より逃避する機序が残存している場合には効果が期待できない。宿主免疫より逃避する機序の解明に役立つ。
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