Investigation of pathology of sensorineural hearing loss from inflammatory cytokines and application for treatment

2022 Fiscal Year Final Research Report

• Project/Area Number: 18K09376
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56050:Otorhinolaryngology-related
• Research Institution: National Hospital Organization Nagoya Medical Center (2022); Nagoya University (2018-2021)
• Principal Investigator: Teranishi Masaaki 独立行政法人国立病院機構(名古屋医療センター臨床研究センター), 耳鼻咽喉科, 医長 (20335037)
• Project Period (FY): 2018-04-01 – 2023-03-31
• Keywords: 内耳 / サイトカイン

Outline of Final Research Achievements

Because genetic factors may contribute partly to the etiologies of inner
ear diseases, we investigated the association between genetic polymorphisms located in genes related to the inflammatory pathway and susceptibility to Meniere disease and tinnitus. We found that uncoupling protein 1, 2 polymorphisms were significantly associated with the risk of tinnitus and platelet glycoprotein Ia polymorphism was associated with the risk of Meniere disease.

Free Research Field

医歯薬

Academic Significance and Societal Importance of the Research Achievements

内耳性難聴や耳鳴は、病態は不明の点が多いが、環境要因や遺伝要因含めた多因子によるものと考えられる。本研究の成果により耳鳴やメニエール病で遺伝要因の関与が考えられた。内耳MRI画像の進歩により内耳血管透過性亢進や内リンパ水腫の評価が可能となった。画像所見も含めて病態を分類し、内耳性難聴や耳鳴の個別化医療に向けての基礎的なデータになることが考えられる。