2018 Fiscal Year Research-status Report
Novel nanomaterials and hybrid soft contact lens for removing fluorouracil from the tear of cancer patients
| Project/Area Number |
18K09469
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| Research Institution | National Institute of Advanced Industrial Science and Technology |
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Principal Investigator |
Ding Wuxiao 国立研究開発法人産業技術総合研究所, 材料・化学領域, 主任研究員 (90598757)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Keywords | Melamine NanoTube / Melamine NanoParticle / 5-FU |
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| Outline of Annual Research Achievements |
I have prepared Melamine NanoTube (MNT) and Melamine NanoParticle (MNP) for the adsorption of 5-FU in aqueous media. The MNT was unable to adsorb 5-FU even at high concentration such as 5000 ng/mL. The porous MNP could adsorb around 90% of 5-FU at 5000 ng/mL that outperformed charcoal. Further, I found that porous MNP with hydrophobic linker outperformed the porous MNP with hydrophilic linker.
However, the present porous MNP showed no absorption ability with 5-FU at low concentration such as 200 ng/mL or lower. The porous MNP shows a BET surface specific area around 48 m2/g, which may be responsible for the weak 5-FU adsorption at 200 ng/mL. These results pointed that increasing the surface area of MNP shall improve the 5-FU adsorption at low concentration.
The lipid for the construction of Melamine NanoTube has been published in scientific journal (Materials Letters, 2019)
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| Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
Melamine NanoParticle that can efficiently adsorb 5-FU has been developed, I also found that porous MNP with hydrophobic linker outperformed the porous MNP with hydrophilic linker. The lipid for the construction of Melamine NanoTube has been published in scientific journal (Materials Letters, 2019)
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| Strategy for Future Research Activity |
The porous MNP should be formulated with higher surface area, either through synthesis process or by using longer alkyl linker, for the adsorption of low concentration 5-FU. The size control of porous MNP and transparent hybrid contact lens seem to be very difficult, therefore turbid hybrid contact lens will be applied for the adsorption experiment at present.
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| Causes of Carryover |
In the last year, the related results were not presented in domestic symposium. Therefore, domestic travelling expense was left over.
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Research Products
(1 results)
