The inhibition of scarring in central and peripheral nerve regeneration

2023 Fiscal Year Final Research Report

• Project/Area Number: 18K09500
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56070:Plastic and reconstructive surgery-related
• Research Institution: The Tazuke Kofukai
• Principal Investigator: ISHIKAWA Namiko 公益財団法人田附興風会, 医学研究所 神経・感覚運動器研究部, 主任研究員 (00462276)
• Co-Investigator(Kenkyū-buntansha): 鈴木 義久 公益財団法人田附興風会, 医学研究所 神経・感覚運動器研究部, 研究主幹 (30243025)
• Project Period (FY): 2018-04-01 – 2024-03-31
• Keywords: 神経 / 再生 / 瘢痕 / 磁場

Outline of Final Research Achievements

We created sciatic nerve and central nerve injury models in 4-week-old rats and examined regeneration under the influence of a magnetic field using a Helmholtz coil.It was suggested that macrophages migrate to the injured area and rapidly remove debris caused by the injury, thereby suppressing fibroblasts. Microarray analysis revealed increased expression of Actn2 and 3, and immunohistochemistry also revealed F-actin in the growth cones of regenerating axons, suggesting that actin may contribute to axon elongation.

Free Research Field

神経再生

Academic Significance and Societal Importance of the Research Achievements

特定の磁場が発生した環境において再生が促されることは非侵襲的であり今後の新しい治療の選択肢になりうると考えられる。