2020 Fiscal Year Final Research Report
Functions of Rho family proteins on hard tissue formation
| Project/Area Number |
18K09512
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 57010:Oral biological science-related
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| Research Institution | Showa University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Keywords | signal transduction |
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| Outline of Final Research Achievements |
The low molecular weight Rho family G proteins Rac1 and Cdc42 serve as molecular switches that transmit various extracellular information into the cell. Regarding cells, it is known that various biological activities, such as cell proliferation, differentiation, and cell death, are regulated mainly through the regulation of actin cytoskeleton. The purpose of this study was to study the functions of Rac1 and Cdc42 genes in hard tissue cells using various inhibitors and activators.
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| Free Research Field |
骨代謝
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| Academic Significance and Societal Importance of the Research Achievements |
Rhoファミリー低分子量Gタンパク質は生体内で様々な機能を有することが細胞レベルおよび生体レベルで知られている。そのため、Rhoファミリー低分子量Gタンパク質中でもRac1およびCdc42の硬組織細胞における機能に関する研究は本研究分野で非常に社会的意義が大きいと考えられる。
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