2020 Fiscal Year Final Research Report

Elucidation of pathology of periodontal disease, sarcopenia, and diabetes centered on inflammation-aging

Research Project

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Project/Area Number	18K09598
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 57030:Conservative dentistry-related
Research Institution	Okayama University
Principal Investigator	Kobayashi Hiroya 岡山大学, 医歯薬学総合研究科, 助教 (20710651)
Co-Investigator(Kenkyū-buntansha)	山本直史岡山大学, 医歯薬学総合研究科, 准教授 (50432662) 山城圭介岡山大学, 大学病院, 講師 (30581087) 高柴正悟岡山大学, 医歯薬学総合研究科, 教授 (50226768)
Project Period (FY)	2018-04-01 – 2021-03-31
Keywords	炎症性老化 / サルコペニア / 慢性炎症 / 歯周炎 / IL-6
Outline of Final Research Achievements	Compared with mature mice (12 weeks old), aged mice (24 weeks old) tended to have more muscle tissue destruction by barium chloride. In the Porphyromonas gingivalis (P.g.) infected group, the number of necrotic cells in muscle tissue tended to be high. Compared with the old model mouse with muscle injury, the periodontitis-old model mouse with muscle injury had a wider range of muscle tissue necrosis and tended to delay healing. The expression level of IL-6 tended to be increased in the old model mouse with muscle injury, and the expression level tended to be higher in the old model mouse with periodontitis-muscle injury.
Free Research Field	歯周病学
Academic Significance and Societal Importance of the Research Achievements	今回の研究において，歯周感染によって筋組織の治癒が悪化する傾向にあり，その背景にIL-6が影響している可能性が示唆された。IL-6は慢性炎症性疾患である歯周炎とサルコペニアを結びつける重要な因子であり，歯周炎症を制御することでサルコペニアの発症・進展予防につながる可能性が示唆される。