Fabrication of low crystalline beta-TCP cancellous bone-like structure by template laminating method

2021 Fiscal Year Final Research Report

• Project/Area Number: 18K09648
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 57040:Regenerative dentistry and dental engineering-related
• Research Institution: Fukuoka Dental College
• Principal Investigator: Maruta Michito 福岡歯科大学, 口腔歯学部, 准教授 (40507802)
• Co-Investigator(Kenkyū-buntansha): 荒平 高章 福岡歯科大学, 口腔歯学部, 助教 (30706958) ; 泉 利雄 福岡歯科大学, 口腔歯学部, 教授 (40248547) ; 梶本 昇 福岡歯科大学, 口腔歯学部, 助教 (30824213)
• Project Period (FY): 2018-04-01 – 2022-03-31
• Keywords: 骨補填材 / 多孔体 / 溶解析出反応

Outline of Final Research Achievements

Semi-hydrated gypsum in dentistry was used as a starting material. This study established how to prepare a porous body with a three-dimensional interconnecting porous structure. Typically, it is known that hydroxyapatite is formed when gypsum is hydrothermally treated, but in this study, a method that can stabilize the precipitation of beta-tricalcium phosphate is a semi-stable phase by using an additive.
The porous gypsum body to which magnesium was added was phase-converted to beta-type calcium phosphate by adjusting the amount of magnesium added and the hydrothermal treatment temperature. It has become possible to develop a porous body that can adjust the porosity by creating a template with a 3D printer and using the curing reaction of gypsum.

Free Research Field

歯科理工学

Academic Significance and Societal Importance of the Research Achievements

ベータ型リン酸三カルシウムは1050℃以上になるとアルファ型リン酸三カルシウムへと相転移（β→α転移）を開始してしまいます。そのため、1050℃より低い温度で焼結させなければならず、焼結密度が低く、強度も小さくなってしまいます。つまり、高温焼結によるベータ型リン酸三カルシウム合成法では内部気孔率（または気孔径）を下げることでしか圧縮強度を向上させることはできません。本研究では低い結晶性を有する完全連通気孔構造を持つ新規ベータ型リン酸三カルシウムの調製法を明らかにした。